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poundmed.com

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Management of Fever—We Know Less Than We Should

 

fever

It is difficult to imagine a time when humans weren’t preoccupied with the mysteries of fever and its treatment. Efforts to probe the pathophysiology of the febrile response are evident as early as 2,500 years ago, when the Sumerians used a pictogram of a aming brazier to symbolize fever. This earliest known effort to conceptualize mechanisms responsible for fever evolved slowly through the humoral theory of the Hippocratic era, the demonic-possession explana­tion of the Middle Ages, the friction and fermen­tation theories of Renaissance iatrophysicists and iatrochemists, to the pyrogen-mediated schema we now accept as valid today.

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